The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast

The Saccharomyces cerevisiae protein Yih1, when overexpressed, inhibits the eIF2 alpha kinase Gcn2 by competing for Gcn1 binding. However, deletion of YIH1 has no detectable effect on Gcn2 activity, suggesting that Yih1 is not a general inhibitor of Gcn2, and has no phenotypic defect identified so f...

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Publicat a:PLoS One
Autors principals: Silva, Richard C., Dautel, Martina, Di Genova, Bruno M., Amberg, David C., Castilho, Beatriz A., Sattlegger, Evelyn
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503747/
https://ncbi.nlm.nih.gov/pubmed/26176233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131070
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