Corruption of the Fas Pathway Delays the Pulmonary Clearance of Murine Osteosarcoma Cells, Enhances Their Metastatic Potential, and Reduces the Effect of Aerosol Gemcitabine

PURPOSE: Pulmonary metastases continue to be a significant problem in osteosarcoma. Apoptosis dysfunction is known to influence tumor development. Fas (CD95, APO-1)/FasL is one of the most extensively studied apoptotic pathways. Because FasL is constitutively expressed in the lung, cells that expres...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Gordon, Nancy, Koshkina, Nadezhda V., Jia, Shu-Fang, Khanna, Chand, Mendoza, Arnulfo, Worth, Laura L., Kleinerman, Eugenie S.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503209/
https://ncbi.nlm.nih.gov/pubmed/17671136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-0313
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