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Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

The equilibrium and kinetics of folding of the single-domain protein chymotrypsin inhibitor 2 conform to the simple two-state model. The structure of the rate-determining transition state has been mapped out at the resolution of individual side chains by using the protein engineering method on 74 mu...

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Detalhes bibliográficos
Main Authors: Otzen, D E, Itzhaki, L S, elMasry, N F, Jackson, S E, Fersht, A R
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC45032/
https://ncbi.nlm.nih.gov/pubmed/7937967
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