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Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.

Cleavage of V(D)J recombination signals by purified RAG1 and RAG2 proteins permits the dissection of DNA structure and sequence requirements. The two recognition elements of a signal (nonamer and heptamer) are used differently, and their cooperation depends on correct helical phasing. The nonamer is...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Ramsden, D A, McBlane, J F, van Gent, D C, Gellert, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450263/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670820/
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