Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance mechanisms. An imbalance in this homeostasis results in pathological accumulations of cerebral Aβ, a characteristic of Alzheimer’s disease (AD). While Aβ may be cleared by several physiological mechanisms, a major...

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Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: Ramanathan, Anita, Nelson, Amy R., Sagare, Abhay P., Zlokovic, Berislav V.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502358/
https://ncbi.nlm.nih.gov/pubmed/26236233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00136
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