Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.
We have established B cell culture systems in which transfected and stably integrated Ig constructs spontaneously undergo high rates of variable (V) region mutation. Mutation rates were determined using reversion analysis of an Ig V region nonsense codon (Vn). A construct (Vn/gamma2a) in which a Vn...
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| Опубликовано в:: | EMBO J |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
1996
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8654371/ |
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