Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.

We have established B cell culture systems in which transfected and stably integrated Ig constructs spontaneously undergo high rates of variable (V) region mutation. Mutation rates were determined using reversion analysis of an Ig V region nonsense codon (Vn). A construct (Vn/gamma2a) in which a Vn...

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Publié dans:	EMBO J
Auteurs principaux:	Zhu, M, Green, N S, Rabinowitz, J L, Scharff, M D
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8654371/
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