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The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.

The current through the L-type calcium channel is inhibited and stimulated by distinct dihydropyridines at very low concentrations. The molecular determinants for the high affinity block and stimulation were investigated using chimeras between the class C and E calcium channels. Mutation of three am...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Schuster, A, Lacinová, L, Klugbauer, N, Ito, H, Birnbaumer, L, Hofmann, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450166/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665843/
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