Immunosuppressive plasma cells impede T cell-dependent immunogenic chemotherapy

Cancer-associated genetic alterations induce expression of tumor antigens which can activate CD8(+) cytotoxic T cells (CTL), but the microenvironment of established tumors promotes immune tolerance through poorly understood mechanisms(1,2). Recently developed therapeutics that overcome tolerogenic m...

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Vydáno v:Nature
Hlavní autoři: Shalapour, Shabnam, Font-Burgada, Joan, Di Caro, Giuseppe, Zhong, Zhenyu, Sanchez-Lopez, Elsa, Dhar, Debanjan, Willimsky, Gerald, Ammirante, Massimo, Strasner, Amy, Hansel, Donna E., Jamieson, Christina, Kane, Christopher J., Klatte, Tobias, Birner, Peter, Kenner, Lukas, Karin, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501632/
https://ncbi.nlm.nih.gov/pubmed/25924065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14395
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