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An Expanded Genetic Code In Mammalian Cells With A Functional Quadruplet Codon

We have utilized in vitro evolution to identify tRNA variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to a quadruplet codon in both bacterial and mammalian cells. This approach will facilitate the creation of an optimized and stan...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Niu, Wei, Schultz, Peter G., Guo, Jiantao
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501474/
https://ncbi.nlm.nih.gov/pubmed/23662731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4001662
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