In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytoto...

Ausführliche Beschreibung

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Veröffentlicht in:Mem Inst Oswaldo Cruz
Hauptverfasser: Lavorato, Stefânia Neiva, Sales, Policarpo Ademar, Murta, Silvane Maria Fonseca, Romanha, Alvaro José, Alves/, Ricardo José
Format: Artigo
Sprache:Inglês
Veröffentlicht: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501422/
https://ncbi.nlm.nih.gov/pubmed/26061148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760150007
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