Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice

TRH-like peptides were synthesized in which the critical N-terminus residue L-pGlu was replaced with various heteroaromatic rings, and the central residue histidine with 1-alkyl-L-histidines. All synthesized TRH-like peptides were evaluated in vitro as agonists in HEK mTRH-R1 and HEK mTRH-R2 cell li...

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Pubblicato in:RSC Adv
Autori principali: Meena, Chhuttan L., Ingole, Shubdha, Rajpoot, Satyendra, Thakur, Avinash, Nandeker, Prajwal P., Sangamwar, Abhay T., Sharma, Shyam S., Jain, Rahul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501038/
https://ncbi.nlm.nih.gov/pubmed/26191403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ra06935a
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