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Molecular architecture of a toxin pore: a 15-residue sequence lines the transmembrane channel of staphylococcal alpha-toxin.

Staphylococcus aureus alpha-toxin is a hydrophilic polypeptide of 293 amino acids that produces heptameric transmembrane pores. During assembly, the formation of a pre-pore precedes membrane permeabilization; the latter is linked to a conformational change in the oligomer. Here, 41 single-cysteine r...

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Udgivet i:EMBO J
Principais autores: Valeva, A, Weisser, A, Walker, B, Kehoe, M, Bayley, H, Bhakdi, S, Palmer, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8617232/
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