The Thymic Orchestration Involving Aire, miRNAs, and Cell–Cell Interactions during the Induction of Central Tolerance

Developing thymocytes interact sequentially with two distinct structures within the thymus: the cortex and medulla. Surviving single-positive and double-positive thymocytes from the cortex migrate into the medulla, where they interact with medullary thymic epithelial cells (mTECs). These cells ectop...

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Udgivet i:Front Immunol
Main Authors: Passos, Geraldo Aleixo, Mendes-da-Cruz, Daniella Arêas, Oliveira, Ernna Hérida
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500981/
https://ncbi.nlm.nih.gov/pubmed/26236310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00352
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