Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction.
Molecular mechanisms of activity-dependent synapse reduction were studied in an in vitro mammalian neuromuscular preparation. Synapse reduction in this model is activity-dependent and is substantially reduced by the broad-spectrum protease inhibitor, leupeptin, suggesting the role of activity-depend...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45007/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7524091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10300 |
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