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Starter Unit Flexibility for Engineered Product Synthesis by the Non-Reducing Polyketide Synthase PksA

Non-reducing polyketide synthases (NR-PKSs) are unique among PKSs in their domain structure, notably including a starter unit:acyl-carrier protein (ACP) transacylase (SAT) domain that selects an acyl group as the primer for biosynthesis, most commonly acetyl-CoA from central metabolism. This clan of...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Huitt-Roehl, Callie R., Hill, Eric A., Adams, Martina M., Vagstad, Anna L., Li, Jesse W., Townsend, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500635/
https://ncbi.nlm.nih.gov/pubmed/25714897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00005
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