Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome

OBJECTIVE: Thombomodulin (TM) is an activator of protein C and a biomarker for endothelial injury. We hypothesized that (1) elevated plasma levels would be associated with clinical outcomes and (2) polymorphisms in the TM gene would be associated with plasma levels. PATIENTS: We studied 449 patients...

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Veröffentlicht in:Intensive Care Med
Hauptverfasser: Sapru, Anil, Calfee, Carolyn S., Liu, Kathleen D., Kangelaris, Kirsten, Hansen, Helen, Pawlikowska, Ludmila, Ware, Lorraine B., Alkhouli, Mustafa F., Abbot, Jason, Matthay, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500527/
https://ncbi.nlm.nih.gov/pubmed/25643902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00134-015-3648-x
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