Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption

AIM: The cysteine protease cathepsin K (CatK), abundantly expressed in osteoclasts, is responsible for the degradation of bone matrix proteins, including collagen type 1. Thus, CatK is an attractive target for new anti-resorptive osteoporosis therapies, but the wider effects of CatK inhibitors on bo...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ren, Zhong-Yuan, Machuca-Gayet, Irma, Domenget, Chantal, Buchet, Rene, Wu, Yuqing, Jurdic, Pierre, Mebarek, Saida
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500499/
https://ncbi.nlm.nih.gov/pubmed/26168340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132513
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