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Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis

BACKGROUND AND PURPOSE: Pro-inflammatory cytokines are important in rheumatoid arthritis (RA) and their production is mainly regulated by NF-κB and inflammasomes. Carboxyamidotriazole (CAI) exhibits potent anti-inflammatory activities by decreasing cytokines. Here, we have investigated NACHT, LRR an...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Zhu, Lei, Li, Juan, Guo, Lei, Yu, Xiaoli, Wu, Danwei, Luo, Lifeng, Zhu, Lingzhi, Chen, Wei, Chen, Chen, Ye, Caiying, Zhang, Dechang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500378/
https://ncbi.nlm.nih.gov/pubmed/25799914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13138
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