Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

BACKGROUND AND PURPOSE: Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation unde...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Br J Pharmacol
Päätekijät: Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G, Sharma, Vishal, Drury, Nigel E, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John D, Feelisch, Martin, Frenneaux, Michael P, Madhani, Melanie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley & Sons, Ltd 2015
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500370/
https://ncbi.nlm.nih.gov/pubmed/25754766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13122
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