Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

BACKGROUND AND PURPOSE: Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation unde...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G, Sharma, Vishal, Drury, Nigel E, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John D, Feelisch, Martin, Frenneaux, Michael P, Madhani, Melanie
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500370/
https://ncbi.nlm.nih.gov/pubmed/25754766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13122
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