Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

BACKGROUND AND PURPOSE: Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation unde...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G, Sharma, Vishal, Drury, Nigel E, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John D, Feelisch, Martin, Frenneaux, Michael P, Madhani, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500370/
https://ncbi.nlm.nih.gov/pubmed/25754766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13122
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