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Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

A glucose-responsive “closed-loop” insulin delivery system mimicking the function of pancreatic cells has tremendous potential to improve quality of life and health in diabetics. Here, we report a novel glucose-responsive insulin delivery device using a painless microneedle-array patch (“smart insul...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yu, Jicheng, Zhang, Yuqi, Ye, Yanqi, DiSanto, Rocco, Sun, Wujin, Ranson, Davis, Ligler, Frances S., Buse, John B., Gu, Zhen
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500284/
https://ncbi.nlm.nih.gov/pubmed/26100900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505405112
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