Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

The use of receptor–ligand interactions to direct toxins to kill diseased cells selectively has shown considerable promise for treatment of a number of cancers and, more recently, autoimmune disease. Here we move the fusion toxin protein (FTP) technology beyond cancer/autoimmune therapeutics to targ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Spiess, Katja, Jeppesen, Mads G., Malmgaard-Clausen, Mikkel, Krzywkowski, Karen, Dulal, Kalpana, Cheng, Tong, Hjortø, Gertrud M., Larsen, Olav, Burg, John S., Jarvis, Michael A., Christopher Garcia, K., Zhu, Hua, Kledal, Thomas N., Rosenkilde, Mette M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500259/
https://ncbi.nlm.nih.gov/pubmed/26080445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509392112
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