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The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes
Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation dominant) vs. more differentiated cells (DNA methylation domin...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500218/ https://ncbi.nlm.nih.gov/pubmed/26100872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422187112 |
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