Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan

Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhao, Longyan, Wu, Mingyi, Xiao, Chuang, Yang, Lian, Zhou, Lutan, Gao, Na, Li, Zi, Chen, Jun, Chen, Jianchao, Liu, Jikai, Qin, Hongbo, Zhao, Jinhua
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500213/
https://ncbi.nlm.nih.gov/pubmed/26100870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504229112
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