Structural and functional insights into Escherichia coli α(2)-macroglobulin endopeptidase snap-trap inhibition

The survival of commensal bacteria requires them to evade host peptidases. Gram-negative bacteria from the human gut microbiome encode a relative of the human endopeptidase inhibitor, α(2)-macroglobulin (α(2)M). Escherichia coli α(2)M (ECAM) is a ∼180-kDa multidomain membrane-anchored pan-peptidase...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Garcia-Ferrer, Irene, Arêde, Pedro, Gómez-Blanco, Josué, Luque, Daniel, Duquerroy, Stephane, Castón, José R., Goulas, Theodoros, Gomis-Rüth, F. Xavier
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500212/
https://ncbi.nlm.nih.gov/pubmed/26100869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506538112
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