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Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade

Synaptic scaling is a form of homeostatic plasticity that stabilizes neuronal firing in response to changes in synapse number and strength. Scaling up in response to action-potential blockade is accomplished through increased synaptic accumulation of GluA2-containing AMPA receptors (AMPAR), but the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gainey, Melanie A., Tatavarty, Vedakumar, Nahmani, Marc, Lin, Heather, Turrigiano, Gina G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500210/
https://ncbi.nlm.nih.gov/pubmed/26109571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510754112
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