Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

Interferon-alpha (IFN alpha) induces rapid tyrosine phosphorylation of its receptors, two JAK kinases and three STAT transcription factors. One kinase, p135tyk2, is complexed with the IFNaR1 receptor, and may catalyze some of these phosphorylation events. We demonstrate that, in vitro, p135tyk2 phos...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Yan, H, Krishnan, K, Greenlund, A C, Gupta, S, Lim, J T, Schreiber, R D, Schindler, C W, Krolewski, J J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450004/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8605876/
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