Outwitting EF-Tu and the ribosome: translation with d-amino acids

Key components of the translational apparatus, i.e. ribosomes, elongation factor EF-Tu and most aminoacyl-tRNA synthetases, are stereoselective and prevent incorporation of d-amino acids (d-aa) into polypeptides. The rare appearance of d-aa in natural polypeptides arises from post-translational modi...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Achenbach, John, Jahnz, Michael, Bethge, Lucas, Paal, Krisztina, Jung, Maria, Schuster, Maja, Albrecht, Renate, Jarosch, Florian, Nierhaus, Knud H., Klussmann, Sven
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499158/
https://ncbi.nlm.nih.gov/pubmed/26026160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv566
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