Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs

A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy and specific gene modification. However, unmodified TFOs have two serious drawbacks: low binding affinities and high sequence-dependencies. In this paper, we propose a new strategy that uses a new set of modifi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ohkubo, Akihiro, Yamada, Kenji, Ito, Yu, Yoshimura, Kiichi, Miyauchi, Koichiro, Kanamori, Takashi, Masaki, Yoshiaki, Seio, Kohji, Yuasa, Hideya, Sekine, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499124/
https://ncbi.nlm.nih.gov/pubmed/26013815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv496
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