Condensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation

The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure(1,2). Here we perform genome-wide chromosome conformation capture analysis, FISH, and RNA-seq to...

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Gepubliceerd in:Nature
Hoofdauteurs: Crane, Emily, Bian, Qian, McCord, Rachel Patton, Lajoie, Bryan R., Wheeler, Bayly S., Ralston, Edward J., Uzawa, Satoru, Dekker, Job, Meyer, Barbara J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498965/
https://ncbi.nlm.nih.gov/pubmed/26030525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14450
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