The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction, including asthma and cystic fibrosis. In the intestine Clca1 is found in the mucus with an abundance and expression pattern similar to Muc2, the ma...

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Publicado en:PLoS One
Main Authors: Erickson, Nancy A., Nyström, Elisabeth E. L., Mundhenk, Lars, Arike, Liisa, Glauben, Rainer, Heimesaat, Markus M., Fischer, André, Bereswill, Stefan, Birchenough, George M. H., Gruber, Achim D., Johansson, Malin E. V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498832/
https://ncbi.nlm.nih.gov/pubmed/26162072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131991
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