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Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells
A commonly activated signaling cascade in many human malignancies including glioblastoma multiforme (GBM) is the Akt pathway. This pathway can be activated via numerous upstream alterations including genomic amplification of EGFR, PTEN deletion, or PIK3CA mutations. In this study, we screened PI3K/A...
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| 發表在: | Mol Cancer Ther |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4498795/ https://ncbi.nlm.nih.gov/pubmed/19208828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0680 |
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