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Applying Pharmacokinetics to Optimize Dosing of Anti-TNF Biologics in Acute Severe Ulcerative Colitis

BACKGROUND: Acute severe ulcerative colitis (ASUC), the most aggressive presentation ulcerative colitis (UC), occurs in 15 percent of adults and children with UC. First line therapy with intravenous corticosteroids is ineffective in half of adults and one third of children. Therapeutic monoclonal an...

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Detalhes bibliográficos
Publicado no:Aliment Pharmacol Ther
Main Authors: Rosen, Michael J., Minar, Philip, Vinks, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498660/
https://ncbi.nlm.nih.gov/pubmed/25809869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.13175
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