Histone Deacetylase Inhibitor Romidepsin Has Differential Activity in Core Binding Factor Acute Myeloid Leukemia

PURPOSE: Recruitment of histone deacetylases (HDAC) is a mechanism of transcriptional repression implicated in the differentiation block in acute myeloid leukemia (AML). We hypothesized that the HDAC inhibitor romidepsin could cause transcriptional derepression, up-regulation of specific target gene...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Odenike, Olatoyosi M., Alkan, Serhan, Sher, Dorie, Godwin, John E., Huo, Dezheng, Brandt, Stephen J., Green, Margaret, Xie, Jingping, Zhang, Yanming, Vesole, David H., Stiff, Patrick, Wright, John, Larson, Richard A., Stock, Wendy
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498482/
https://ncbi.nlm.nih.gov/pubmed/18981008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1007
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