A hyperactive piggyBac transposon system is an easy-to-implement method for introducing foreign genes into mouse preimplantation embryos

Transgenic mice are important tools for genetic analysis. A current prominent method for producing transgenic mice involves pronuclear microinjection into 1-cell embryos. However, the total transgenic efficiency obtained using this method is less than 10%. Here, we demonstrate that highly efficient...

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Bibliographic Details
Published in:J Reprod Dev
Main Authors: SUZUKI, Shinnosuke, TSUKIYAMA, Tomoyuki, KANEKO, Takehito, IMAI, Hiroshi, MINAMI, Naojiro
Format: Artigo
Language:Inglês
Published: The Society for Reproduction and Development 2015
Subjects:
Technology Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498375/
https://ncbi.nlm.nih.gov/pubmed/25740401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2014-157
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