Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

OBJECTIVES: (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H(37)Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-substituted tetrahydroisoquinolines was undert...

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Dades bibliogràfiques
Publicat a:J Antimicrob Chemother
Autors principals: Guzman, Juan D., Pesnot, Thomas, Barrera, Diana A., Davies, Heledd M., McMahon, Eleanor, Evangelopoulos, Dimitrios, Mortazavi, Parisa N., Munshi, Tulika, Maitra, Arundhati, Lamming, Eleanor D., Angell, Richard, Gershater, Markus C., Redmond, Joanna M., Needham, Deborah, Ward, John M., Cuca, Luis E., Hailes, Helen C., Bhakta, Sanjib
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498294/
https://ncbi.nlm.nih.gov/pubmed/25656411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv010
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