Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

OBJECTIVES: (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H(37)Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-substituted tetrahydroisoquinolines was undert...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Guzman, Juan D., Pesnot, Thomas, Barrera, Diana A., Davies, Heledd M., McMahon, Eleanor, Evangelopoulos, Dimitrios, Mortazavi, Parisa N., Munshi, Tulika, Maitra, Arundhati, Lamming, Eleanor D., Angell, Richard, Gershater, Markus C., Redmond, Joanna M., Needham, Deborah, Ward, John M., Cuca, Luis E., Hailes, Helen C., Bhakta, Sanjib
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498294/
https://ncbi.nlm.nih.gov/pubmed/25656411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv010
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