Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

OBJECTIVES: (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H(37)Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-substituted tetrahydroisoquinolines was undert...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Main Authors: Guzman, Juan D., Pesnot, Thomas, Barrera, Diana A., Davies, Heledd M., McMahon, Eleanor, Evangelopoulos, Dimitrios, Mortazavi, Parisa N., Munshi, Tulika, Maitra, Arundhati, Lamming, Eleanor D., Angell, Richard, Gershater, Markus C., Redmond, Joanna M., Needham, Deborah, Ward, John M., Cuca, Luis E., Hailes, Helen C., Bhakta, Sanjib
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498294/
https://ncbi.nlm.nih.gov/pubmed/25656411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv010
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