Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells

The mitogen-activated protein kinase kinase 4 (MKK4) is activated via phosphorylation of Ser-257 and Thr-261 by upstream MAP3Ks and activates JNK and p38 MAPKs in response to cellular stress. We show that thioredoxin (Trx), a cellular redox protein, activates MKK4 via Cys-246 and Cys-266 residues as...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kundumani-Sridharan, Venkatesh, Subramani, Jaganathan, Das, Kumuda C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498085/
https://ncbi.nlm.nih.gov/pubmed/26028649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660365
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