Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography

Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglutamine repeat in the protein product, leading to m...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Darrow, Michele C., Sergeeva, Oksana A., Isas, Jose M., Galaz-Montoya, Jesús G., King, Jonathan A., Langen, Ralf, Schmid, Michael F., Chiu, Wah
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498080/
https://ncbi.nlm.nih.gov/pubmed/25995452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655373
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