Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography

Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglutamine repeat in the protein product, leading to m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Darrow, Michele C., Sergeeva, Oksana A., Isas, Jose M., Galaz-Montoya, Jesús G., King, Jonathan A., Langen, Ralf, Schmid, Michael F., Chiu, Wah
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498080/
https://ncbi.nlm.nih.gov/pubmed/25995452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655373
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