Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography

Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglutamine repeat in the protein product, leading to m...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Darrow, Michele C., Sergeeva, Oksana A., Isas, Jose M., Galaz-Montoya, Jesús G., King, Jonathan A., Langen, Ralf, Schmid, Michael F., Chiu, Wah
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498080/
https://ncbi.nlm.nih.gov/pubmed/25995452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655373
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