Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography

Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglutamine repeat in the protein product, leading to m...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Darrow, Michele C., Sergeeva, Oksana A., Isas, Jose M., Galaz-Montoya, Jesús G., King, Jonathan A., Langen, Ralf, Schmid, Michael F., Chiu, Wah
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498080/
https://ncbi.nlm.nih.gov/pubmed/25995452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655373
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