Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32

Tryptophan was substituted for residues in all four transmembrane domains of connexin32. Function was assayed using dual cell two-electrode voltage clamp after expression in Xenopus oocytes. Tryptophan substitution was poorly tolerated in all domains, with the greatest impact in TM1 and TM4. For ins...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Brennan, Matthew J., Karcz, Jennifer, Vaughn, Nicholas R., Woolwine-Cunningham, Yvonne, DePriest, Adam D., Escalona, Yerko, Perez-Acle, Tomas, Skerrett, I. Martha
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498046/
https://ncbi.nlm.nih.gov/pubmed/25969535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650747
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars