Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

T-cell defects, immune suppression, and poor antitumor immune responses are hallmarks of chronic lymphocytic leukemia (CLL), and PD-1/PD-L1 inhibitory signaling has emerged as a major immunosuppressive mechanism. However, the effect of different microenvironments and the confounding influence of agi...

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Опубликовано в: :Blood
Главные авторы: McClanahan, Fabienne, Riches, John C., Miller, Shaun, Day, William P., Kotsiou, Eleni, Neuberg, Donna, Croce, Carlo M., Capasso, Melania, Gribben, John G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2015
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497962/
https://ncbi.nlm.nih.gov/pubmed/25979947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-626754
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