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Insights into disease-associated mutations in the human proteome through protein structural analysis

Most known disease-associated mutations are missense mutations involving changes of amino acids of proteins encoded by their genes. Given the plethora of genetic studies, sequenced exomes, and new protein structures determined each year, it is appropriate to revisit the role that structure plays in...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Gao, Mu, Zhou, Hongyi, Skolnick, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497952/
https://ncbi.nlm.nih.gov/pubmed/26027735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.03.028
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