BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations

A transition from fetal hemoglobin (HbF) to adult hemoglobin (HbA) normally occurs within a few months after birth. Increased production of HbF after this period of infancy ameliorates clinical symptoms of the major disorders of adult β-hemoglobin: β-thalassemia and sickle cell disease. The transcri...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Basak, Anindita, Hancarova, Miroslava, Ulirsch, Jacob C., Balci, Tugce B., Trkova, Marie, Pelisek, Michal, Vlckova, Marketa, Muzikova, Katerina, Cermak, Jaroslav, Trka, Jan, Dyment, David A., Orkin, Stuart H., Daly, Mark J., Sedlacek, Zdenek, Sankaran, Vijay G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497765/
https://ncbi.nlm.nih.gov/pubmed/25938782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81163
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