Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hanson, Melissa C., Crespo, Monica P., Abraham, Wuhbet, Moynihan, Kelly D., Szeto, Gregory L., Chen, Stephanie H., Melo, Mariane B., Mueller, Stefanie, Irvine, Darrell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497758/
https://ncbi.nlm.nih.gov/pubmed/25938786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79915
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