Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

Bach1 is a transcriptional repressor of heme oxygenase-1 and β-globin genes, both of which are known to be transcriptionally induced by heme. To test the hypothesis that heme regulates the activity of Bach1, we expressed wild type and mutated versions of Bach1 together with or without its heterodime...

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Veröffentlicht in:EMBO J
Hauptverfasser: Suzuki, Hiroshi, Tashiro, Satoshi, Hira, Shusuke, Sun, Jiying, Yamazaki, Chikara, Zenke, Yukari, Ikeda-Saito, Masao, Yoshida, Minoru, Igarashi, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2004
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Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15175654/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600248
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