Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions

The mammalian target of rapamycin (mTOR) correlates with cell survival under hypoxia and regulates hypoxia-inducible factor-1α (HIF-1α), a key protein in hypoxia-related events. However, the role of mTOR in radio-resistance has not been fully investigated. Therefore, the effect of mTOR on the radio-...

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Vydáno v:J Radiat Res
Hlavní autoři: Ushijima, Hiroki, Suzuki, Yoshiyuki, Oike, Takahiro, Komachi, Mayumi, Yoshimoto, Yuya, Ando, Ken, Okonogi, Noriyuki, Sato, Hiro, Noda, Shin-ei, Saito, Jun-ichi, Nakano, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497394/
https://ncbi.nlm.nih.gov/pubmed/25887043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrv021
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